Through the entire 2014-2015 school year, Brennan missed more school than he made. The uphill battle of being 5 years behind in math and grammar was met with an even steeper grade, as his peers continued to move along at their customary pace while Brennan, although moving forward, moved so at a rate crucially slower than his classmates. Still, he hung in there the best he could. Yet, through a combination of another of God’s many miracles, and a sympathetically cooperative school, he managed to get enough done to finish 7th grade with his classmates.
Earlier in the year, however, Tara and I were faced with what appeared to be the most frightening news of his post 4th transplant rehabilitation. After his annual February check-up (represented the primary annual barrage of biopsies and tests, performed at the anniversary of the fourth transplant) we learned that his chimerism had slipped. The chimerism is the test that determines the ratio of donor stem cells to that of the host. Being that the goal is to have 100% of one’s immune system replaced by the donor, Brennan’s had slipped to 98%. Even 1% of his own immune system is too large, as any part of his original immune system would be cancerous. We returned to St Jude in April to determine a game plan, whether to address the problem with less immune suppressants, thereby allowing the new immune system to take firmer root. The risk, however, would be chronic GVHD, the number 1 killer of transplant patients outside of relapse. The other option would be DLI (donor lymphocyte infusion), where we jump started the immune system with more stem cells from the donor (his mom). This terrified us.
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